An Unbiased View of indazole alkylation
An Unbiased View of indazole alkylation
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-indazoles 3a–q/4a–l in up to 87% yields. The reaction requires a totally free-radical system and proceeds by means of
The indazole Main is an interesting pharmacophore as a consequence of its purposes in medicinal chemistry. Up to now few years, this moiety is useful for the synthesis of kinase inhibitors.
Indazoles are a category of heterocyclic compounds that has a bicyclic ring structure made up of a pyrazole ring along with a benzene ring. Indazole-containing compounds with numerous useful groups have essential pharmacological pursuits and can be employed as structural motifs in building novel drug molecules.
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The operationally very simple, oxidant-promoted protocol reveals various useful group tolerances and vast substrate compatibilities. The reaction entails a totally free-radical system and proceeds through